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5 top scientists share the progress of new tools and new methods of gene editing technology

Original Wiley Wiley 2021-04-08

In recent years, gene editing technology has developed rapidly, and innovative gene editing technologies have emerged one after another. In particular , the innovative gene editing system represented by CRISPR/CAS has greatly improved the efficiency of gene editing and reduced application costs. There are broad application prospects in the treatment of major and rare diseases, precision medicine, microbial modification, and animal and plant genetic breeding technologies. • Germany's Max Planck Institute for the etiology of Emmanuelle Charpentier doctor and the University of California, Berkeley, Jennifer A. Doudna doctor because CRISPR / CAS outstanding original contributions made by technology, was awarded the 2020 Nobel Prize in Chemistry.

In order to further reveal the cutting-edge hotspots and future trends in this field, and to promote the exchanges between Chinese researchers and top scientists and editors in the discipline , Wiley specially invited five scientists from different disciplines to discuss with us new tools and new gene editing technology. Method progress.

This online forum was hosted by Professor Gao Caixia, a researcher at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and invited Yang Sheng, a researcher at the Center for Excellence in Molecular Plant Science / Institute of Plant Physiology and Ecology, and Cong Le, Assistant Professor, Stanford University School of Medicine Wang Yanli, a researcher at the Institute of Biophysics, Chinese Academy of Sciences, Li Dali, a researcher at the School of Life Sciences, East China Normal University , Wu Yan, the editorial director of Wiley's life and social sciences, as well as Shen Huixuan, director of the development editorial department of Wiley's life science special issue , and Zhang Xiaoyu, full-time editor of Wiley's life sciences, launched the theme sharing and roundtable discuss. The forum is free and open to the vast number of scientific researchers, and a question and answer time is set at the same time, and everyone is welcome to sign up and participate!

Online forum time

4 Yue 21 Ri (Zhousan) morning 9:00 - 11:00

way of participation

Long press to scan the following QR code or copy the link to register for free

https://register.gotowebinar.com/register/4382362391266762509

Speaker introduction

Gao Caixia

Researcher, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

Gao Caixia, PhD, researcher, and doctoral supervisor. 1997 was awarded PhD China Agricultural University, 1997-1998 Denmark DLF-Trifolium company postdoctoral research department. 1998-2009 , Research Scientist , research team leader of the scientific research department of DLF-Trifolium , Denmark . 2009 Nian 9 Yue returning home, a researcher at the State Key Laboratory of Genetics and Developmental Plant Cell and Chromosome Engineering, project leader, currently Director of the Institute of genome editing center. In 2010 , he was selected as the "Outstanding Technical Talent" of the Chinese Academy of Sciences. In 2017 , he won the National Innovation Award and Tan Jiazhen Life Science Innovation Award. In the same year, he was selected into the National Hundred and Thousand Talents Project. Mainly engaged in the research of plant genome editing technology, biosafety new breeding technology and genome editing directed design molecular breeding, and is committed to promoting the application of genome editing in molecular design breeding.

Yang Sheng

Researcher, Center for Excellence in Molecular Plant Science, Chinese Academy of Sciences / Institute of Plant Physiology and Ecology

Yang Sheng, graduated from Zhejiang University with a bachelor's degree in 1995 , and graduated with a Ph.D. from the Shanghai Institute of Biochemistry, Chinese Academy of Sciences in 2000. He has worked at the Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (now the Center for Excellence in Molecular Plant Science, Chinese Academy of Sciences). One of the research directions of Yang Sheng's laboratory is to develop microbial genome editing tools to accelerate cell construction to understand related genetic and biochemical mechanisms, and then design a new generation of engineered cells to help green chemistry and biomedicine. The genome editing tool plasmids published by the research group have been distributed more than 2,000 times, and more than 10 domestic and foreign companies have been commercially authorized . Yang Sheng has won the Addgene Blue Flame Award , DuPont Young Professor Award, Novozymes Innovation Award, special government allowance of the State Council and the National Science Fund for Outstanding Youth.

Cong Le

Assistant Professor, Stanford University School of Medicine

Cong Le is an assistant professor in the Department of Pathology and Genetics at Stanford University School of Medicine, a member of the Cancer Center, Neuroscience Center, and BioX Interdisciplinary Research Center. The laboratory is committed to combining gene editing, single cell analysis, and AI computational biology, developing precise treatment technologies and studying the molecular mechanisms of complex diseases, especially tumor immunity and autoimmune related diseases. Selected as Clarivate Safety Ball Highly Cited Scientist, GEN BioTech Top10Under40 . Has won the Class Scholarship, Tsinghua University, HHMI international postgraduate award, CSC self-financed students special Award of Excellence, CRI Irvington postdoctoral funding, Donald and Delia Baxter Foundation 2019 Young Scholar Award, and 2020 Nian NIH gene Innovation Award.

Wang Yanli

Researcher, Institute of Biophysics, Chinese Academy of Sciences

Wang Yanli, doctoral researcher and doctoral supervisor. He graduated from the University of Science and Technology of China in 2004 with a PhD. From 2006 to 2011 , he worked as a postdoctoral fellow, associate researcher, and senior researcher at the Sloan - Katherine Cancer Research Center in the United States . Winner of the "Hundred Talents Program" of the Chinese Academy of Sciences, leader of the Innovation Project Group of the Beijing Key Laboratory of Non-coding Nucleic Acid. The main research direction is the structure and function of RNA interference ( RNA interference , RNA ) related proteins. 2016 Nian 11 months, won the ninth, "Tan Jiazhen Life Sciences Innovation Award." 2017 Nian 02 months, won the thirteenth "China Youth Female Scientist Award."

Li Dali

Researcher, School of Life Sciences, East China Normal University

Li Dali, Ph.D., researcher, doctoral supervisor, and winner of the Outstanding Youth Fund of the School of Life Sciences, East China Normal University. He received his Ph.D. degree in genetics from Hunan Normal University in 2007 and has been working in East China Normal University after graduation. He is currently the director of Minhang Experimental Animal Center of East China Normal University and the deputy director of Shanghai Key Laboratory of Regulatory Biology. Over the years, based on the optimization and transformation of gene editing technology, the model construction and gene therapy of rare diseases have been carried out in-depth research, and more than 90 papers have been published in high-level journals such as Nature Biotechnology , Nature Cell Biology and Nature Genetics , as the project leader He presided over the key research and development projects of the Ministry of Science and Technology, a major project of the Shanghai Municipal Education Commission, and won the first prize of the Young Yangtze River Scholar of the Ministry of Education and the Natural Science Award for Outstanding Achievements in Scientific Research of Higher Education.

The " Wiley Science Spotlight " series of online forums aims to discuss the hotspots and future trends of life science research, promote exchanges between Chinese researchers and top scientists and editors, and enhance the scientific research literacy and capabilities of researchers. For related activities and more information about Wiley life science journals and special issues, please follow the " Wiley Research Service" WeChat service account (search for " wileyresearch " or long press the following QR code to follow).